Clinical Trials

NCT IdNCT04106973
TitleMesothelioma Early Detection by VOCs
ConditionPleural Mesothelioma
StudyTypeObservational
OrganizationAscension South East Michigan
Sponsor/CollaboratorsAscension South East Michigan
StatusRecruiting
GenderAll
AgeGroupAdult
Older Adult
Location (with distance)
  • Consultants in Sleep and Pulmonary Medicine, Farmington Hills, 48336 , United States
DescriptionThis is a two phase study, The first phase (phase 1) will identify potential biomarkers among asbestos exposed individuals with pleural mesothelioma. The second phase (phase 2), is a double blinded case-matched controlled study to determine the predictive capability, sensitivity, and specificity of these biomarkers in detecting early stage pleural mesothelioma. Biomarkers in the form of volatile organic compounds (VOC) in exhaled breath samples from subjects with either pleural mesothelioma or pleural plaques, will be evaluated. A biomarker present in serum will also be concurrently evaluated in the same cohort. The soluble serum biomarker mesothelin related peptides (SMRP), which has been posited as a biomarker for mesothelioma, will be analyzed for its relationship to the breath VOC profile.