Clinical Trials

NCT IdNCT04872439
TitleNovel Antineuronal Antibodies in Gastrointestinal Motility Disorders
ConditionAutoimmune Gastrointestinal Dysmotility
OrganizationJohns Hopkins University
Sponsor/CollaboratorsJohns Hopkins University
Older Adult
Location (with distance)
  • Johns Hopkins Bayview Medical Center, Baltimore, 21224 , United States
DescriptionGastrointestinal motility disorders represent a heterogeneous group of neuromuscular diseases of the enteric nervous systems. While autoimmune neuromuscular diseases of the central nervous system (CNS) are well described, the role of autoimmunity in enteric nervous system (ENS) has been less studied. Approximately 10% of patients with unexplained gastrointestinal dysmotility diseases have positive serum autoantibodies to peripheral nervous system proteins, suggesting an autoimmune mechanism targeting the enteric nervous system. Our aim is to identify novel anti neuronal antibodies that contribute to autoimmune gastrointestinal motility disorders by analyzing the serum of patients with abnormal gastrointestinal motility.